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Report of Multilocus Inherited Neoplasia Alleles Syndrome in a Chilean Oncology Institute: New Combinations and Genetic Landscape.

Genes - 22 Jul 2026

Sepúlveda Bustos Francisca, Martin Merlez Fernanda, Campos Jadrijevic Danitza, Saavedra María Paz, Selman Bravo Carolina

Abstract excerpt

Background/Objectives: Multilocus Inherited Neoplasia Alleles Syndrome (MINAS) is defined by the presence of germline pathogenic or likely pathogenic variants in two or more distinct cancer susceptibility genes (CSGs) in the same individual. Although carriers may present more complex phenotypes, the clinical and molecular spectrum of MINAS remains poorly characterized, particularly in underrepresented...

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Identifiers

PMID: 42510879
DOI: 10.3390/genes17070839
PMCID: PMC13410221

Genes

ATM
CDKN2A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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