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Article

Multi-locus inherited neoplasia alleles syndromes in cancer: implications for clinical practice.

European journal of human genetics : EJHG - 1 Mar 2025

Yuen Jeanette, Zhou Siqin, Caeser Rebecca, Venkatramani Mallika, Bte Ishak Diana Nur, Li Shao-Tzu, Zhang Zewen, Chiang Jianbang, Chan Sock Hoai, Ngeow Joanne

Abstract excerpt

The popularity of multi-gene testing has identified more families with two or more pathogenic variants (PV) in cancer predisposition genes, also known as 'MINAS' (multilocus inherited neoplasia alleles syndromes). They are at risk of suboptimal treatment and management as little on this topic is known. We conducted a systematic review of published MINAS cases within cancer predisposition genes to understand their...

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Identifiers

PMID: 39843919
DOI: 10.1038/s41431-025-01785-1
PMCID: PMC11894078

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