Hereditary and Familial Tumor Syndromes: When to Think of Them? The Emerging Role of Pathologists as Sentinels of Genetic Cancer Predisposition.

Abstract excerpt

Germline predisposition contributes to at least 10% of human malignancies and is identified in ∼8.5% to 10% of pediatric cancers, with notably higher frequencies in specific tumor types, including over 60% in adrenocortical carcinoma and 17% to 20% in osteosarcoma. In certain tumors, hereditary predisposition is a defining or highly characteristic feature. Advances in next-generation sequencing have significantly...

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