Article
Genetic vaccines to potentiate the effective CD103+ dendritic cell-mediated cross-priming of antitumor immunity.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2015
Zhang Yi, Chen Guo, Liu Zuqiang, Tian Shenghe, Zhang Jiying, Carey Cara D, Murphy Kenneth M, Storkus Walter J, Falo Louis D, You Zhaoyang
Abstract excerpt
The development of effective cancer vaccines remains an urgent, but as yet unmet, clinical need. This deficiency is in part due to an incomplete understanding of how to best invoke dendritic cells (DC) that are crucial for the induction of tumor-specific CD8(+) T cells capable of mediating durable protective immunity. In this regard, elevated expression of the transcription factor X box-binding protein 1 (XBP1)...
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