Article
PI3Kγ in hypertension: a novel therapeutic target controlling vascular myogenic tone and target organ damage.
Cardiovascular research - 1 Sept 2012
Carnevale Daniela, Lembo Giuseppe
Abstract excerpt
In the past decade, several studies have characterized a number of cellular and molecular mechanisms that contribute to the regulation of the vascular myogenic response, thus affecting blood pressure regulation. Recently, phosphoinositide 3-kinase γ (PI3Kγ) has been identified as a main regulator of vascular myogenic tone and blood pressure, a result further strengthened by a highly significant genome-wide...
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