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Article

Metabolic characterisation of disturbances in the APOC3/triglyceride-rich lipoprotein pathway through sample-based recall by genotype.

Metabolomics : Official journal of the Metabolomic Society - 3 Jun 2020

Corbin Laura J, Hughes David A, Chetwynd Andrew J, Taylor Amy E, Southam Andrew D, Jankevics Andris, Weber Ralf J M, Groom Alix, Dunn Warwick B, Timpson Nicholas J

Abstract excerpt

INTRODUCTION: High plasma triacylglyceride levels are known to be associated with increased risk of atherosclerotic cardiovascular disease. Apolipoprotein C-III (apoC-III) is a key regulator of plasma triacylglyceride levels and is associated with hypertriglyceridemia via a number of pathways. There is consistent evidence for an association of cardiovascular events with blood apoC-III level, with support from...

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PMID: 32494907
DOI: 10.1007/s11306-020-01689-9
PMCID: PMC7270992

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