Article
Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis.
Nature cell biology - 1 Sept 2015
Yuan Lin, Lv Yanrong, Li Hongchang, Gao Haidong, Song Shanshan, Zhang Yuan, Xing Guichun, Kong Xiangzhen, Wang Lijing, Li Yang, Zhou Tao, Gao Daming, Xiao Zhi-Xiong, Yin Yuxin, Wei Wenyi, He Fuchu, Zhang Lingqiang
Abstract excerpt
PTEN is one of the most frequently mutated tumour suppressors and reduction in PTEN protein stability also plays a role in tumorigenesis. Although several ubiquitin ligases for PTEN have been identified, the deubiquitylase for de-polyubiquitylation and stabilization of PTEN is less defined. Here, we report OTUD3 as a deubiquitylase of PTEN. OTUD3 interacts with, de-polyubiquitylates and stabilizes PTEN. Depletion...
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