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Potential Regulatory Role of Human-Carboxylesterase-1 Glycosylation in Liver Cancer Cell Growth

18 Nov 2020

Abstract excerpt

We previously reported that human carboxylesterase 1 (CES1), a serine esterase containing a unique N -linked glycosyl group at Asn79 (N79 CES1), is a candidate serological marker of hepatocellular carcinoma (HCC). CES1 is normally present at low-to-undetectable levels in normal human plasma, HCC tumors, and major liver cancer cell lines. To investigate the potential mechanism underlying the suppression of CES1...

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PMID: 33206527
DOI: 10.1021/acs.jproteome.0c00787

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