Article
Infectious dengue vesicles derived from CD61+ cells in acute patient plasma exhibited a diaphanous appearance.
Scientific reports - 11 Dec 2015
Hsu Alan Yi-Hui, Wu Shang-Rung, Tsai Jih-Jin, Chen Po-Lin, Chen Ya-Ping, Chen Tsai-Yun, Lo Yu-Chih, Ho Tzu-Chuan, Lee Meed, Chen Min-Ting, Chiu Yen-Chi, Perng Guey Chuen
Abstract excerpt
The levels of neutralizing antibody to a pathogen are an effective indicator to predict efficacy of a vaccine in trial. And yet not all the trial vaccines are in line with the theory. Using dengue virus (DENV) to investigate the viral morphology affecting the predictive value, we evaluated the viral morphology in acute dengue plasma compared to that of Vero cells derived DENV. The virions in plasma were...
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