In vitro characterization of engineered red blood cells as viral traps against HIV-1 and SARS-CoV-2

Abstract excerpt

Engineered red blood cells (RBCs) expressing viral receptors could be used therapeutically as viral traps, as RBCs lack nuclei and other organelles required for viral replication. However, expression of viral receptors on RBCs is difficult to achieve since mature erythrocytes lack the cellular machinery to synthesize proteins. Herein, we show that the combination of a powerful erythroid-specific expression system...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Erythrocyte Function and Pathophysiology
• Share to Phagocytosis and Immune Regulation
• Share to SARS-CoV-2 and COVID-19 Research