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Article

How antibodies alter the cell entry pathway of dengue virus particles in macrophages

7 Jul 2016

Abstract excerpt

Antibody-dependent enhancement of dengue virus (DENV) infection plays an important role in the exacerbation of DENV-induced disease. To understand how antibodies influence the fate of DENV particles, we explored the cell entry pathway of DENV in the absence and presence of antibodies in macrophage-like P388D1 cells. Recent studies unraveled that both mature and immature DENV particles contribute to ADE, hence,...

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PMID: 27385443
DOI: 10.1038/srep28768

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