Article
A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis.
Developmental cell - 7 Dec 2015
Laguesse Sophie, Creppe Catherine, Nedialkova Danny D, Prévot Pierre-Paul, Borgs Laurence, Huysseune Sandra, Franco Bénédicte, Duysens Guérin, Krusy Nathalie, Lee Gabsang, Thelen Nicolas, Thiry Marc, Close Pierre, Chariot Alain, Malgrange Brigitte, Leidel Sebastian A, Godin Juliette D, Nguyen Laurent
Abstract excerpt
The cerebral cortex contains layers of neurons sequentially generated by distinct lineage-related progenitors. At the onset of corticogenesis, the first-born progenitors are apical progenitors (APs), whose asymmetric division gives birth directly to neurons. Later, they switch to indirect neurogenesis by generating intermediate progenitors (IPs), which give rise to projection neurons of all cortical layers. While...
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