Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanisms underlying neural cell death in neurodegenerative diseases: alterations of a developmentally-mediated cellular rheostat.

Trends in neurosciences - 1 Dec 2000

Mehler M F, Gokhan S

Abstract excerpt

Genes associated with neurodegenerative diseases are normally expressed throughout neural development and are essential for the elaboration and maintenance of neuronal subpopulations. Disease-causing mutations can compromise defined subsets of these neural specification events in subtle ways that initially lead to impairments in the cellular homeostasis of evolving regional neuronal subpopulations, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Death
Share to Genes, Regulator
Share to Huntington Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Proteins

Share to Neurodegenerative Diseases

Share to Neurons

Share to Presenilin-1

Share to Signal Transduction

Source

Identifiers

PMID: 11137149
DOI: 10.1016/s0166-2236(00)01705-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanisms underlying neural cell death in neurodegenerative diseases: alterations of a developmentally-mediated cellular rheostat.PMID 11137149Read ↗

Degenerative disorders of the central nervous system.Semantic proximity Read ↗

Common and Divergent Mechanisms in Developmental Neuronal Remodeling and Dying Back NeurodegenerationSemantic proximity Read ↗

Molecular and cellular mechanisms of selective vulnerability in neurodegenerative diseasesSemantic proximity Read ↗

Neuronal Cell Death Mechanisms in Major Neurodegenerative DiseasesSemantic proximity Read ↗

DNA Repair Deficiency and NeurodegenerationSemantic proximity Read ↗

Defective Neural Stem and Progenitor Cell Proliferation in Neurodevelopmental DisordersSemantic proximity Read ↗

Programmed Cell Death in the Developing Nervous SystemSemantic proximity Read ↗

At the Crossroads Between Neurodegeneration and Cancer: A Review of Overlapping Biology and Its ImplicationsSemantic proximity Read ↗

Phenotypic checkpoints regulate neuronal development.Semantic proximity Read ↗

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs).Semantic proximity Read ↗

Ferroptosis in neurodegenerative diseases: mechanisms and therapeutic potential of stem cell derivativesSemantic proximity Read ↗

A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.