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Article

ITPA Genotypes Predict Anemia but Do Not Affect Virological Response with Interferon-Free Faldaprevir, Deleobuvir, and Ribavirin for HCV Infection.

PloS one - 1 Jan 2015

Asselah Tarik, Zeuzem Stefan, Soriano Vicente, Bronowicki Jean-Pierre, Lohse Ansgar W, Müllhaupt Beat, Schuchmann Marcus, Bourlière Marc, Buti Maria, Roberts Stuart K, Gane Edward J, Stern Jerry O, Voss Florian, Baum Patrick, Gallivan John-Paul, Böcher Wulf O, Mensa Federico J

Abstract excerpt

BACKGROUND & AIM: Whether inosine triphosphatase (ITPA) gene polymorphisms predict anemia during interferon-free therapy in chronic hepatitis C virus (HCV)-infected patients is unknown. We examined the relationship between two ITPA polymorphisms, anemia, and sustained virological response 12 weeks post-treatment (SVR12) in patients receiving the NS3/4A protease inhibitor faldaprevir, the non-nucleoside polymerase...

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Identifiers

PMID: 26650626
DOI: 10.1371/journal.pone.0144004
PMCID: PMC4674133

Genes

ITPA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ITPA Genotypes Predict Anemia but Do Not Affect Virological Response with Interferon-Free Faldaprevir, Deleobuvir, and Ribavirin for HCV Infection.PMID 26650626Read ↗

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Model incorporating the ITPA genotype identifies patients at high risk of anemia and treatment failure with pegylated-interferon plus ribavirin therapy for chronic hepatitis C.Semantic proximity Read ↗

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Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia and decrease the need for ribavirin dose reduction.Semantic proximity Read ↗

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Association of ITPA gene polymorphisms and the risk of ribavirin-induced anemia in HIV/hepatitis C virus (HCV)-coinfected patients receiving HCV combination therapy.Semantic proximity Read ↗

Association of ITPA polymorphisms rs6051702/rs1127354 instead of rs7270101/rs1127354 as predictor of ribavirin-associated anemia in chronic hepatitis C treated patients.Semantic proximity Read ↗

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