Article
Association of ITPA polymorphisms rs6051702/rs1127354 instead of rs7270101/rs1127354 as predictor of ribavirin-associated anemia in chronic hepatitis C treated patients.
Antiviral research - 1 Oct 2013
D'Avolio Antonio, De Nicolò Amedeo, Cusato Jessica, Ciancio Alessia, Boglione Lucio, Strona Silvia, Cariti Giuseppe, Troshina Giulia, Caviglia Gian Paolo, Smedile Antonina, Rizzetto Mario, Di Perri Giovanni
Abstract excerpt
Functional variants rs7270101 and rs1127354 of inosine triphosphatase (ITPA) were recently found to protect against ribavirin (RBV)-induced hemolytic anemia. However, no definitive data are yet available on the role of no functional rs6051702 polymorphism. Since a simultaneous evaluation of the three ITPA SNPs for hemolytic anemia has not yet been investigated, we aimed to understand the contribution of each SNPs...
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