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Article

Inosine triphosphate pyrophosphohydrolase activity: more accurate predictor for ribavirin-induced anemia in hepatitis C infected patients than ITPA genotype.

Clinical chemistry and laboratory medicine - 1 Nov 2015

Peltenburg Nicole Chantal, Bakker Jaap A, Vroemen Wim H M, de Knegt Robert J, Leers Mathie P G, Bierau Jörgen, Verbon Annelies

Abstract excerpt

BACKGROUND: ITPA polymorphisms have been associated with protection against ribavirin-induced anemia in chronic hepatitis C (HCV) patients. Here we determined the association of inosine triphosphate pyrophosphohydrolase (inosine triphosphatase or ITPase) enzyme activity with ITPA genotype in predicting ribavirin-induced anemia. METHODS: In a cohort of 106 HCV patients, hemoglobin (Hb) values were evaluated after...

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Identifiers

PMID: 25968438
DOI: 10.1515/cclm-2015-0057

Genes

ITPA

Variants

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Inosine triphosphate pyrophosphohydrolase activity: more accurate predictor for ribavirin-induced anemia in hepatitis C infected patients than ITPA genotype.PMID 25968438Read ↗

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