Article
Inosine triphosphatase polymorphisms and ribavirin pharmacokinetics as determinants of ribavirin-associate anemia in patients receiving standard anti-HCV treatment.
Therapeutic drug monitoring - 1 Apr 2012
DʼAvolio Antonio, Ciancio Alessia, Siccardi Marco, Smedile Antonina, Baietto Lorena, Simiele Marco, Marucco Diego Aguilar, Cariti Giuseppe, Calcagno Andrea, de Requena Daniel Gonzalez, Sciandra Mauro, Cusato Jessica, Troshina Giulia, Bonora Stefano, Rizzetto Mario, Di Perri Giovanni
Abstract excerpt
BACKGROUND: Functional variants of inosine triphosphatase (ITPA) were recently found to protect against ribavirin (RBV)-induced hemolytic anemia. However, no definitive data are yet available on the role of plasma RBV concentrations on hemoglobin (Hb) decrement. Moreover, no data have been published on the possible interplay between these 2 factors. METHODS: A retrospective analysis included 167 patients. The...
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