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Article

Common genetic polymorphism of ITPA gene affects ribavirin-induced anemia and effect of peg-interferon plus ribavirin therapy.

Journal of medical virology - 1 Jun 2011

Azakami Takahiro, Hayes C Nelson, Sezaki Hitomi, Kobayashi Mariko, Akuta Norio, Suzuki Fumitaka, Kumada Hiromitsu, Abe Hiromi, Miki Daiki, Tsuge Masataka, Imamura Michio, Kawakami Yoshiiku, Takahashi Shoichi, Ochi Hidenori, Nakamura Yusuke, Kamatani Naoyuki, Chayama Kazuaki

Abstract excerpt

An association between a single nucleotide polymorphism (SNP) in the inosine triphosphate pyrophosphatase (ITPA) gene and reduction of hemoglobin during peg-interferon plus ribavirin combination therapy for patients with chronic hepatitis C virus (HCV) infection has been reported. However, the effect of the SNP on outcome of therapy has not been fully elucidated. Factors associated with anemia during combination...

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Share to Anemia
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hepatitis C, Chronic

Share to Interferon-alpha

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Share to Ribavirin

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Source

Identifiers

PMID: 21503919
DOI: 10.1002/jmv.22069

Genes

ITPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Common genetic polymorphism of ITPA gene affects ribavirin-induced anemia and effect of peg-interferon plus ribavirin therapy.PMID 21503919Read ↗

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ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy--a genome-wide study of Japanese HCV virus patients.Semantic proximity Read ↗

Association between IPTA gene polymorphisms and hematological abnormalities in hepatitis C virus-infected patients receiving combination therapy.Semantic proximity Read ↗

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Polymorphism of the inosine triphosphate pyrophosphatase gene predicts ribavirin-induced anemia in chronic hepatitis C patients.Semantic proximity Read ↗

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Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia in HIV/HCV-coinfected patients with all HCV genotypes.Semantic proximity Read ↗

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