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Ceramide synthase 4 overexpression exerts oncogenic properties in breast cancer

26 Oct 2023

Abstract excerpt

BACKGROUND: Ceramide, a bioactive signaling sphingolipid, has long been implicated in cancer. Members of the ceramide synthase (CerS) family determine the acyl chain lengths of ceramides, with ceramide synthase 4 (CerS4) primarily generating C18-C20-ceramide. Although CerS4 is known to be overexpressed in breast cancer, its role in breast cancer pathogenesis is not well established. METHODS: To investigate the...

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PMID: 37885013
DOI: 10.1186/s12944-023-01930-z

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