Aberrant regulation of serine metabolism drives extracellular vesicle release and cancer progression

Abstract excerpt

Cancer cells secrete extracellular vesicles (EVs) to regulate cells in the tumor microenvironment to benefit their own growth and survive in the patient’s body. Although emerging evidence has demonstrated the molecular mechanisms of EV release, regulating cancer-specific EV secretion remains challenging. In this study, we applied a microRNA library to reveal the universal mechanisms of EV secretion from cancer cel...

Topics

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• Autophagy in Disease and Therapy
• Cell Adhesion Molecules Research
• Drug Transport and Resistance Mechanisms
• Endoplasmic Reticulum Stress and Disease
• Extracellular vesicles in disease
• MicroRNA in disease regulation
• Phagocytosis and Immune Regulation
• Sphingolipid Metabolism and Signaling

Identifiers and source

Literature Corpus work

9e3ebe68-50bb-581f-93ab-b55bdf6e3d3f

DOI

10.1101/2022.05.10.491299