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Golgicide A induces pyroptosis of lung cancer stem cells by regulating dTGN formation via GOLPH3/MYO18A complex

7 Mar 2025

Abstract excerpt

BACKGROUND: Lung cancer is a common malignant neoplasm, one of the leading causes of death worldwide. Cancer stem cells (CSCs) drive tumor recurrence, progression, and therapeutic resistance. Thus, targeting CSCs may contribute to lung cancer treatment and improve clinical outcomes. METHODS: We induced stem cell formation in serum-free suspension culture. Cell viability was assessed using the cell counting-kit 8...

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PMID: 40055842
DOI: 10.1186/s13287-025-04246-0

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