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Investigational nucleoside and nucleotide polymerase inhibitors and their use in treating hepatitis C virus

21 May 2014

Abstract excerpt

INTRODUCTION: About 150 million people worldwide are estimated to be chronically infected with the hepatitis C virus (HCV). Successful antiviral treatment can stop the progression of the disease toward liver cirrhosis, hepatocellular carcinoma and death. IFN has been the drug of choice and the backbone of all combinations in the past two decades. However, an IFN-free combination (sofosbuvir and ribavirin) has...

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PMID: 24848437
DOI: 10.1517/13543784.2014.921680

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