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Article

2-Heteroarylimino-5-arylidene-4-thiazolidinones as a new class of non-nucleoside inhibitors of HCV NS5B polymerase.

European journal of medicinal chemistry - 1 Nov 2013

Küçükgüzel Ilkay, Satılmış Gökhan, Gurukumar K R, Basu Amartya, Tatar Esra, Nichols Daniel B, Talele Tanaji T, Kaushik-Basu Neerja

Abstract excerpt

Hepatitis C virus (HCV) NS5B polymerase is an important and attractive target for the development of anti-HCV drugs. Here we report on the design, synthesis and evaluation of twenty-four novel allosteric inhibitors bearing the 4-thiazolidinone scaffold as inhibitors of HCV NS5B polymerase. Eleven compounds tested were found to inhibit HCV NS5B with IC₅₀ values ranging between 19.8 and 64.9 μM. Compound 24 was the...

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Identifiers

PMID: 24161679
DOI: 10.1016/j.ejmech.2013.08.043
PMCID: PMC4004375

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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