Article
IGHV mutational status of nodal marginal zone lymphoma by NGS reveals distinct pathogenic pathways with different prognostic implications.
Virchows Archiv : an international journal of pathology - 1 Jul 2020
Granai Massimo, Amato Teresa, Di Napoli Arianna, Santi Raffaella, Vergoni Federica, Di Stefano Gioia, Mancini Virginia, Kovalchuk Sofya, Cencini Emanuele, Carta Alberto Giulio, Aversa Sara, Ziepert Marita, Cevenini Gabriele, Lazzi Stefano, Leoncini Lorenzo, Bellan Cristiana
Abstract excerpt
The precise B cell of origin and molecular pathogenesis of nodal marginal zone lymphoma (NMZL) remain poorly defined. To date, due to the rarity of NMZL, the vast majority of already-published studies have been conducted on a limited number of samples and the technical approach to analyze the immunoglobulin genes was of amplifying rearranged variable region genes with the classical direct sequencing of the PCR...
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