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Article

SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment.

Nature communications - 8 Dec 2015

Mian Syed A, Rouault-Pierre Kevin, Smith Alexander E, Seidl Thomas, Pizzitola Irene, Kizilors Aytug, Kulasekararaj Austin G, Bonnet Dominique, Mufti Ghulam J

Abstract excerpt

Despite the recent evidence of the existence of myelodysplastic syndrome (MDS) stem cells in 5q-MDS patients, it is unclear whether haematopoietic stem cells (HSCs) could also be the initiating cells in other MDS subgroups. Here we demonstrate that SF3B1 mutation(s) in our cohort of MDS patients with ring sideroblasts can arise from CD34(+)CD38(-)CD45RA(-)CD90(+)CD49f(+) HSCs and is an initiating event in disease...

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Identifiers

PMID: 26643973
DOI: 10.1038/ncomms10004
PMCID: PMC4686651

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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