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Induction of autophagy improves embryo viability in cloned mouse embryos

8 Dec 2015

Abstract excerpt

Autophagy is an essential cellular mechanism that degrades cytoplasmic proteins and organelles to recycle their components. Moreover, autophagy is essential for preimplantation development in mammals. Here we show that autophagy is also important for reprogramming in somatic cell nuclear transfer (SCNT). Our data indicate that unlike fertilized oocytes, autophagy is not triggered in SCNT embryos during 6 hours of...

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PMID: 26643778
DOI: 10.1038/srep17829

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