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HER2 mutation status in Japanese HER2-positive breast cancer patients.

Breast cancer (Tokyo, Japan) - 1 Nov 2016

Endo Yumi, Dong Yu, Kondo Naoto, Yoshimoto Nobuyasu, Asano Tomoko, Hato Yukari, Nishimoto Mayumi, Kato Hiroyuki, Takahashi Satoru, Nakanishi Ryoichi, Toyama Tatsuya

Abstract excerpt

BACKGROUND: Human epidermal growth factor receptor 2 (HER2) gene amplification/overexpression is a major therapeutic target in breast cancer, and has been introduced as a predictive biomarker to identify patients who may benefit from therapy with anti-HER2 agents. HER2 somatic mutations have been reported, and these may influence the effect of HER2-targeted drugs. METHODS: Here, we sought HER2 mutations in a...

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PMID: 26642960
DOI: 10.1007/s12282-015-0659-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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