Article
Prognostic and predictive implications of HER2/ERBB2/neu gene mutations in lung cancers.
Lung cancer (Amsterdam, Netherlands) - 1 Oct 2011
Tomizawa Kenji, Suda Kenichi, Onozato Ryoichi, Kosaka Takayuki, Endoh Hideki, Sekido Yoshitaka, Shigematsu Hisayuki, Kuwano Hiroyuki, Yatabe Yasushi, Mitsudomi Tetsuya
Abstract excerpt
BACKGROUND: Activating mutation in the kinase domain of the human EGF receptor 2 (HER2) gene (also known as ERBB2 or neu) is reported to be present in a small fraction of lung adenocarcinomas. However its prognostic and predictive implications are not yet established. PATIENTS AND METHODS: We examined 504 Japanese lung cancer patients who underwent pulmonary resection for HER2 mutations by direct sequencing and...
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