Clinical and pathological characterization of HER2 mutations in human breast cancer: a systematic review of the literature.

Abstract excerpt

PURPOSE: HER2 gene is a member of the epidermal growth factor receptor (EGFR) family. Across different malignancies, aberrations of HER2 gene commonly correspond to gain-of-function alterations leading to increased receptor signaling. METHODS: We have reviewed the literature currently available on HER2 mutations in human breast cancer (BC) evaluating type and frequency of such mutations. The primary objective was...

Topics

Join the communities discussing this publication.

• Breast Neoplasms
• Gene Amplification
• EGFR gene
• Genetic Predisposition to Disease
• Mutation