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Article

HER2 somatic mutations are associated with poor survival in HER2-negative breast cancers.

Cancer science - 1 Apr 2017

Wang Tonghui, Xu Ye, Sheng Shuyan, Yuan Hua, Ouyang Tao, Li Jinfeng, Wang Tianfeng, Fan Zhaoqing, Fan Tie, Lin Benyao, Xie Yuntao

Abstract excerpt

It is well documented that human epidermal growth factor receptor 2 (HER2) overexpression/amplification is associated with poor survival in breast cancer patients. However, it is largely unknown whether HER2 somatic mutations are associated with survival in HER2-negative breast cancer patients. Here, we identified HER2 somatic mutations in tumors from 1348 unselected breast cancer patients by sequencing the...

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Identifiers

PMID: 28164408
DOI: 10.1111/cas.13182
PMCID: PMC5406600

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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