Article

Genome-Wide Identification of HES1 Target Genes Uncover Novel Roles for HES1 in Pancreatic Development

2018-05-31

Abstract excerpt

Notch signalling and the downstream effector HES1 is required for multiple pancreatic cell fate choices during development, but the direct target genes remain poorly characterised. Here we identify direct HES1 target genes on a genome-wide scale using ChIP-seq and RNA-seq analyses combined with human embryonic stem cell (hESC) directed differentiation of CRISPR/Cas9-generated HES1 -/- mutant hESC lines. We found...

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Literature Corpus work: aaf37436-80c9-592e-9f94-e7acb374ed6d
DOI: 10.1101/335869

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