Article
HLA-G 3'UTR Polymorphisms Predict Drug-Induced G3-4 Toxicity Related to Folinic Acid/5-Fluorouracil/Oxaliplatin (FOLFOX4) Chemotherapy in Non-Metastatic Colorectal Cancer.
International journal of molecular sciences - 27 Jun 2017
Garziera Marica, Virdone Saverio, De Mattia Elena, Scarabel Lucia, Cecchin Erika, Polesel Jerry, D'Andrea Mario, Pella Nicoletta, Buonadonna Angela, Favaretto Adolfo, Toffoli Giuseppe
Abstract excerpt
Polymorphisms in drug-metabolizing enzymes might not completely explain inter-individual differences in toxicity profiles of patients with colorectal cancer (CRC) that receive folinic acid/5-fluorouracil/oxaliplatin (FOLFOX4). Recent data indicate that the immune system could contribute to FOLFOX4 outcomes. In light of the immune inhibitory nature of human leukocyte antigen-G (HLA-G), a non-classical major...
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