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Systematic microcarrier screening and agitated culture conditions improves human mesenchymal stem cell yield in bioreactors

3 Dec 2015

Abstract excerpt

Production of human mesenchymal stem cells for allogeneic cell therapies requires scalable, cost-effective manufacturing processes. Microcarriers enable the culture of anchorage-dependent cells in stirred-tank bioreactors. However, no robust, transferable methodology for microcarrier selection exists, with studies providing little or no reason explaining why a microcarrier was employed. We systematically...

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PMID: 26632496
DOI: 10.1002/biot.201400862

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