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Article

Large-Scale Expansion and Differentiation of Mesenchymal Stem Cells in Microcarrier-Based Stirred Bioreactors.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2016

Sart Sébastien, Agathos Spiros N

Abstract excerpt

Mesenchymal stem cells (MSCs) have emerged as an important tool for tissue engineering, thanks to their differentiation potential and their broad trophic activities. However, for clinical purposes or for relevant in vitro applications, large quantities of MSCs are required, which could hardly be reached using conventional cultivation in plastic dishes. Microcarriers have high surface to volume ratio, which...

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PMID: 26892015
DOI: 10.1007/7651_2015_314

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MSC

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