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Efficient expansion and delayed senescence of hUC-MSCs by microcarrier–bioreactor system

4 Oct 2023

Abstract excerpt

BACKGROUND: Human umbilical cord mesenchymal stem cells (hUC-MSCs) are widely used in cell therapy due to their robust immunomodulatory and tissue regenerative capabilities. Currently, the predominant method for obtaining hUC-MSCs for clinical use is through planar culture expansion, which presents several limitations. Specifically, continuous cell passaging can lead to cellular aging, susceptibility to...

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PMID: 37794520
DOI: 10.1186/s13287-023-03514-1

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