Article
Toward Personalized Lymphoma Immunotherapy: Identification of Common Driver Mutations Recognized by Patient CD8+ T Cells.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 May 2016
Nielsen Julie S, Sedgwick Colin G, Shahid Aniqa, Zong Zusheng, Brumme Zabrina L, Yu Stephen, Liu Lewis, Kroeger David R, Treon Steven P, Connors Joseph M, Gascoyne Randy D, Berry Brian R, Marra Marco A, Morin Ryan D, Macpherson Nicol, Nelson Brad H
Abstract excerpt
PURPOSE: A fundamental challenge in the era of next-generation sequencing (NGS) is to design effective treatments tailored to the mutational profiles of tumors. Many newly discovered cancer mutations are difficult to target pharmacologically; however, T-cell-based therapies may provide a valuable alternative owing to the exquisite sensitivity and specificity of antigen recognition. To explore this concept, we...
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