Article

Neoantigen Landscape Supports Feasibility of Personalized Cancer Vaccine for Follicular Lymphoma

2022-01-10

Abstract excerpt

Personalized cancer vaccines designed to target neoantigens represent a promising new treatment paradigm in oncology. In contrast to classical idiotype vaccines, we hypothesized that ‘polyvalent’ vaccines could be engineered for the personalized treatment of follicular lymphoma (FL) using neoantigen discovery by combined whole exome sequencing (WES) and RNA sequencing (RNA-Seq). Fifty-eight tumor samples from 57 p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eed39688-fa19-5271-b113-82150327a015
DOI: 10.1101/2022.01.06.22268805

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Neoantigen Landscape Supports Feasibility of Personalized Cancer Vaccine for Follicular LymphomaDOI 10.1101/2022.01.06.22268805Read

Neoantigen landscape supports feasibility of personalized cancer vaccine for follicular lymphoma.Semantic proximity Read

It's a long way to the top (if you want to personalize immunotherapy).Semantic proximity Read

Applications of Next-Generation Sequencing in Neoantigen Prediction and Cancer Vaccine DevelopmentSemantic proximity Read

Immune microenvironment subtypes and association with tumor cell mutations and antigen expression in follicular lymphomaSemantic proximity Read

Neoantigen-based personalized cancer vaccines: the emergence of precision cancer immunotherapySemantic proximity Read

Follicular Lymphoma Microenvironment Characteristics Associated with Tumor Cell Mutations and MHC Class II ExpressionSemantic proximity Read

Synthetic multiepitope neoantigen DNA vaccine for personalized cancer immunotherapy.Semantic proximity Read

Toward Personalized Lymphoma Immunotherapy: Identification of Common Driver Mutations Recognized by Patient CD8+ T Cells.Semantic proximity Read

Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens.Semantic proximity Read

Systematic identification of personal tumor-specific neoantigens in chronic lymphocytic leukemia.Semantic proximity Read

Prediction and prioritization of neoantigens: integration of RNA sequencing data with whole‐exome sequencingSemantic proximity Read

<i>In vitro</i> validation of neoantigen prediction algorithm for developing personalized cancer vaccine therapySemantic proximity Read