Genetic variants in IL12 influence both hepatitis B virus clearance and HBV-related hepatocellular carcinoma development in a Chinese male population.

doi:10.1007/s13277-015-4520-x

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Article

Genetic variants in IL12 influence both hepatitis B virus clearance and HBV-related hepatocellular carcinoma development in a Chinese male population.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 May 2016

Tan Aihua, Gao Yong, Yao Ziting, Su Shining, Jiang Yonghua, Xie Yuanliang, Xian Xiaoying, Mo Zengnan

Abstract excerpt

IL12 plays a major role not only in inducing appropriate immune responses against viral infections (including HBV) but also in the antitumor immune response. This study was conducted to investigate the relationships of genetic variants in IL12 with hepatitis B virus (HBV) clearance and development of HBV-related hepatocellular carcinoma (HCC). We genotyped three single nucleotide polymorphisms (SNPs) of the IL12A...

Topics

Adult
Asian People
Carcinoma, Hepatocellular
China
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Haplotypes
Hepatitis B virus
Hepatitis B, Chronic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Interleukin-12

Liver Neoplasms

Male

Middle Aged

Polymorphism, Single Nucleotide

Source

Open in PubMed

Identifiers

PMID: 26631030
DOI: 10.1007/s13277-015-4520-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-26631030-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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