Article
Gene polymorphisms of TLR2 and TLR3 in HBV clearance and HBV-related hepatocellular carcinoma in a Chinese male population.
The International journal of biological markers - 4 May 2017
Chen Dongni, Xie Weimin, Lu Yongkui, Su Shining, Nong Li, Jia Yuxian, Liu Yan, Zhou Wenxian, Wang Hongxue, Tan Aihua
Abstract excerpt
BACKGROUND: The Toll-like receptor plays an essential role in controlling immunity and inflammation. This study was to investigate the relationships of genetic variants in TLR2 and TLR3 with hepatitis B virus (HBV) natural clearance and HBV-related hepatocellular carcinoma (HCC) risk in a Chinese male population. METHODS: We analyzed 5 polymorphisms of TLR2 (rs3804099 and rs3804100) and TLR3 (rs5743305, rs3775296...