Article
In Vivo Models for Cholangiocarcinoma-What Can We Learn for Human Disease?
International journal of molecular sciences - 15 Jul 2020
Mohr Raphael, Özdirik Burcin, Knorr Jana, Wree Alexander, Demir Münevver, Tacke Frank, Roderburg Christoph
Abstract excerpt
Cholangiocarcinoma (CCA) comprises a heterogeneous group of primary liver tumors. They emerge from different hepatic (progenitor) cell populations, typically via sporadic mutations. Chronic biliary inflammation, as seen in primary sclerosing cholangitis (PSC), may trigger CCA development. Although several efforts were made in the last decade to better understand the complex processes of biliary carcinogenesis, it...
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