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Article

Common G102S polymorphism in chitotriosidase differentially affects activity towards 4-methylumbelliferyl substrates.

The FEBS journal - 1 Oct 2009

Bussink Anton P, Verhoek Marri, Vreede Jocelyne, Ghauharali-van der Vlugt Karen, Donker-Koopman Wilma E, Sprenger Richard R, Hollak Carla E, Aerts Johannes M F G, Boot Rolf G

Abstract excerpt

Chitotriosidase (CHIT1) is a chitinase that is secreted by activated macrophages. Plasma chitotriosidase activity reflects the presence of lipid-laden macrophages in patients with Gaucher disease. CHIT1 activity can be conveniently measured using fluorogenic 4-methylumbelliferyl (4MU)-chitotrioside or 4MU-chitobioside as the substrate, however, nonsaturating concentrations have to be used because of apparent...

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Source

Identifiers

PMID: 19725875
DOI: 10.1111/j.1742-4658.2009.07259.x

Genes

CHIT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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