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Article

Mechanism of hydrogen activation by [NiFe] hydrogenases.

Nature chemical biology - 1 Jan 2016

Evans Rhiannon M, Brooke Emily J, Wehlin Sara A M, Nomerotskaia Elena, Sargent Frank, Carr Stephen B, Phillips Simon E V, Armstrong Fraser A

Abstract excerpt

The active site of [NiFe] hydrogenases contains a strictly conserved arginine that suspends a guanidine nitrogen atom <4.5 Å above the nickel and iron atoms. The guanidine headgroup interacts with the side chains of two conserved aspartic acid residues to complete an outer-shell canopy that has thus far proved intractable to investigation by site-directed mutagenesis. Using hydrogenase-1 from Escherichia coli,...

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PMID: 26619250
DOI: 10.1038/nchembio.1976

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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