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Article

Characterization of the Bottlenecks and Pathways for Inhibitor Dissociation from [NiFe] Hydrogenase.

Journal of chemical information and modeling - 27 May 2024

Sohraby Farzin, Nunes-Alves Ariane

Abstract excerpt

[NiFe] hydrogenases can act as efficient catalysts for hydrogen oxidation and biofuel production. However, some [NiFe] hydrogenases are inhibited by gas molecules present in the environment, such as O2 and CO. One strategy to engineer [NiFe] hydrogenases and achieve O2- and CO-tolerant enzymes is by introducing point mutations to block the access of inhibitors to the catalytic site. In this work, we characterized...

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Identifiers

PMID: 38728115
DOI: 10.1021/acs.jcim.4c00187
PMCID: PMC11134402

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Characterization of the Bottlenecks and Pathways for Inhibitor Dissociation from [NiFe] Hydrogenase.PMID 38728115Read ↗

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