Article
Principles of sustained enzymatic hydrogen oxidation in the presence of oxygen--the crucial influence of high potential Fe-S clusters in the electron relay of [NiFe]-hydrogenases.
Journal of the American Chemical Society - 20 Feb 2013
Evans Rhiannon M, Parkin Alison, Roessler Maxie M, Murphy Bonnie J, Adamson Hope, Lukey Michael J, Sargent Frank, Volbeda Anne, Fontecilla-Camps Juan C, Armstrong Fraser A
Abstract excerpt
"Hyd-1", produced by Escherichia coli , exemplifies a special class of [NiFe]-hydrogenase that can sustain high catalytic H(2) oxidation activity in the presence of O(2)-an intruder that normally incapacitates the sulfur- and electron-rich active site. The mechanism of "O(2) tolerance" involves a critical role for the Fe-S clusters of the electron relay, which is to ensure the availability-for immediate transfer...
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