Article
Single-Amino Acid Modifications Reveal Additional Controls on the Proton Pathway of [FeFe]-Hydrogenase.
Biochemistry - 7 Jun 2016
Cornish Adam J, Ginovska Bojana, Thelen Adam, da Silva Julio C S, Soares Thereza A, Raugei Simone, Dupuis Michel, Shaw Wendy J, Hegg Eric L
Abstract excerpt
The proton pathway of [FeFe]-hydrogenase is essential for enzymatic H2 production and oxidation and is composed of four residues and a water molecule. A computational analysis of this pathway in the [FeFe]-hydrogenase from Clostridium pasteurianum revealed that the solvent-exposed residue of the pathway (Glu282) forms hydrogen bonds to two residues outside of the pathway (Arg286 and Ser320), implying that these...
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