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Article

Single Amino Acid Switch between a Flavin-Dependent Dehalogenase and Nitroreductase.

Journal of the American Chemical Society - 16 Dec 2015

Mukherjee Arnab, Rokita Steven E

Abstract excerpt

A single mutation within a flavoprotein is capable of switching the catalytic activity of a dehalogenase into a nitroreductase. This change in function correlates with a destabilization of the one-electron-reduced flavin semiquinone that is differentially expressed in the nitro-FMN reductase superfamily during redox cycling. The diversity of function within such a superfamily therefore has the potential to arise...

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Identifiers

PMID: 26616824
DOI: 10.1021/jacs.5b07540
PMCID: PMC4684082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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