Article
Nicotinamide Adenine Dinucleotides Arrest Photoreduction of Class II DNA Photolyases in FADH˙ State.
Photochemistry and photobiology - 1 Jan 2018
Ignatz Elisabeth, Geisselbrecht Yann, Kiontke Stephan, Essen Lars-Oliver
Abstract excerpt
All light-sensitive members of the photolyase/cryptochrome family rely on FAD as catalytic cofactor. Its activity is regulated by photoreduction, a light-triggered electron transfer process from a conserved tryptophan triad to the flavin. The stability of the reduced flavin depends on available external electron donors and oxygen. In this study, we show for the class II photolyase of Methanosarcina mazei,...
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