Article
Genotype-Directed Dosing Leads to Optimized Voriconazole Levels in Pediatric Patients Receiving Hematopoietic Stem Cell Transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Mar 2016
Teusink Ashley, Vinks Alexander, Zhang Kejian, Davies Stella, Fukuda Tsuyoshi, Lane Adam, Nortman Shannon, Kissell Diane, Dell Sarah, Filipovich Alexandra, Mehta Parinda
Abstract excerpt
Invasive fungal infections are a significant cause of morbidity and mortality in recipients of hematopoietic stem cell transplantation (HSCT), warranting antifungal prophylaxis as a standard of care in these patients. Voriconazole is commonly used in this setting because of its broad-spectrum activity and available dosage forms. There is wide well-known inter- and intrapatient variability in voriconazole...
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