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Article

Pharmacogenetic and clinical predictors of voriconazole concentration in hematopoietic stem cell transplant recipients receiving CYP2C19-guided dosing.

The pharmacogenomics journal - 1 Nov 2023

Patel Jai N, Robinson Myra, Morris Sarah A, Jandrisevits Elizabeth, Lopes Karine Eboli, Hamilton Alicia, Steuerwald Nury, Druhan Lawrence J, Avalos Belinda, Copelan Edward, Ghosh Nilanjan, Grunwald Michael R

Abstract excerpt

CYP2C19-guided voriconazole dosing reduces pharmacokinetic variability, but many patients remain subtherapeutic. The aim of this study was to evaluate the effect of candidate genes and a novel CYP2C haplotype on voriconazole trough concentrations in patients receiving CYP2C19-guided dosing. This is a retrospective candidate gene study in allogeneic hematopoietic cell transplant (HCT) patients receiving...

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Identifiers

PMID: 37925536
DOI: 10.1038/s41397-023-00320-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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