Article
Identification of Hsp90 as a species independent H5N1 avian influenza A virus PB2 interacting protein.
Comparative immunology, microbiology and infectious diseases - 1 Dec 2015
Jirakanwisal Krit, Srisutthisamphan Kanjana, Thepparit Chutima, Suptawiwat Ornpreya, Auewarakul Prasert, Paemanee Atchara, Roytrakul Sittiruk, Smith Duncan R
Abstract excerpt
The avian influenza polymerase protein PB2 subunit is an important mediator of cross species adaptation and adaptation to mammalian cells is strongly but not exclusively associated with an adaptive mutation of the codon at position 627 of the PB2 protein which alters the glutamate normally found at this position to a lysine. This study sought to identify host cell factors in both mammalian and avian cells that...
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